abstract：BACKGROUND:Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disorder of the central nervous system. NMO and its abortive forms are referred to as NMO spectrum disorders (NMOSD). NMOSD are mostly associated with antibodies to aquaporin-4 (AQP4-IgG). However, recent studies have demonstrated antibodies to m...

journal_title：Journal of the neurological sciences

authors： Bouzar M,Daoudi S,Hattab S,Bouzar AA,Deiva K,Wildemann B,Reindl M,Jarius S

更新日期：2017-10-15 00:00:00

abstract：:Both proprietary and non-proprietary medicines are expected to undergo rigorous pre-approval testing and both should meet stringent health authority regulatory requirements related to quality to obtain approval. Non-proprietary (also known as copy or generic) medicines, which base their authorization and use on the pr...

journal_title：Journal of the neurological sciences

authors： Correale J

更新日期：2017-10-15 00:00:00

abstract：:Few studies have explored the role of microRNAs (or miRNAs) in Amyotrophic Lateral Sclerosis (ALS) muscle, possibly because of the difficulty in obtaining samples and because this is a rare disease. We measured the expression levels of muscle-specific miRNAs (miRNA-1, miRNA-206, miRNA-133a, miRNA-133b, miRNA-27a) and ...

journal_title：Journal of the neurological sciences

authors： Pegoraro V,Merico A,Angelini C

更新日期：2017-09-15 00:00:00

abstract：:Glioblastoma (GBM) is the most common primary malignant brain tumor in adults over 55years of age. The median age of diagnosis for patients with GBM is 64years old, with the incidence of patients between 75 and 85 increasing. The optimal treatment paradigm for elderly GBM patients continues to evolve due to the higher...

journal_title：Journal of the neurological sciences

authors： Young JS,Chmura SJ,Wainwright DA,Yamini B,Peters KB,Lukas RV

更新日期：2017-09-15 00:00:00

abstract：OBJECTIVE:Naftopidil is used clinically for the treatment of voiding disorders in benign prostatic hyperplasia. Previous in vivo experiments in which naftopidil was applied intrathecally abolished rhythmic bladder contraction, suggesting that naftopidil might inhibit a voiding reflex through interaction with spinal dor...

journal_title：Journal of the neurological sciences

authors： Uta D,Xie DJ,Hattori T,Kasahara KI,Yoshimura M

更新日期：2017-09-15 00:00:00

abstract：INTRODUCTION:The NR4A2 transcription factor is important in the development, survival and phenotype of dopaminergic neurons and it is postulated as a possible biomarker for Parkinson's disease (PD). Therefore, our aim was to analyze in a sample of a Mexican population with idiopathic PD, mutations (in two hotspot mutat...

journal_title：Journal of the neurological sciences

authors： Ruiz-Sánchez E,Yescas P,Rodríguez-Violante M,Martínez-Rodríguez N,Díaz-López JN,Ochoa A,Valdes-Rojas SS,Magos-Rodríguez D,Rojas-Castañeda JC,Cervantes-Arriaga A,Canizales-Quinteros S,Rojas P

更新日期：2017-08-15 00:00:00

abstract：OBJECTIVE:This study investigated the utility of sideline concussion tests, including components of the Sports Concussion Assessment Tool, 3rd Edition (SCAT3) and the King-Devick (K-D), a vision-based test of rapid number naming, in an outpatient, multidisciplinary concussion center treating patients with both sports-r...

journal_title：Journal of the neurological sciences

authors： Kyle Harrold G,Hasanaj L,Moehringer N,Zhang I,Nolan R,Serrano L,Raynowska J,Rucker JC,Flanagan SR,Cardone D,Galetta SL,Balcer LJ

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:Unilateral spatial neglect (USN) is frequently found in ischemic stroke patients. Because USN is related to poor functional outcomes, evaluating recovery from USN after stroke is critical. METHODS:Patients with acute ischemic stroke with lesions in the right cerebral hemisphere on MRI and exhibiting left US...

journal_title：Journal of the neurological sciences

authors： Kamakura CK,Ueno Y,Sakai Y,Yoshida H,Aiba S,Hayashi A,Shimura H,Takeda K,Kamakura K,Hattori N,Urabe T

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:Endocrine dysfunction is known to occur in various infectious diseases of the brain. The neuroendocrine dysfunction is not well studied in patients of Tuberculous meningitis (TBM). In this study, we aimed at knowing pattern of endocrine dysfunction in newly diagnosed patients of tuberculous meningitis, struc...

journal_title：Journal of the neurological sciences

authors： More A,Verma R,Garg RK,Malhotra HS,Sharma PK,Uniyal R,Pandey S,Mittal M

更新日期：2017-08-15 00:00:00

abstract：INTRODUCTION:'No evidence of disease activity' (NEDA) is increasingly used as a treatment target with disease-modifying drugs for relapsing multiple sclerosis. METHODS:This post-hoc analysis of the randomised EVIDENCE trial compared interferon beta-1a injected subcutaneously three times weekly (IFN β-1a SC tiw) with i...

journal_title：Journal of the neurological sciences

authors： Coyle PK,Reder AT,Freedman MS,Fang J,Dangond F

更新日期：2017-08-15 00:00:00

abstract：:There is ample evidence of an important role of descending serotonergic projections in modulating spinal motor neuron activation and firing, and experimental studies suggest that 5-HT receptor stimulation can improve motor function after spinal cord injury; however, relevant clinical data is sorely lacking. We describ...

journal_title：Journal of the neurological sciences

authors： Horvath GA,Meisner L,Selby K,Stowe R,Carleton B

更新日期：2017-07-15 00:00:00

abstract：BACKGROUND:Despite the recent advances in the understanding of natalizumab (NTZ) related progressive multifocal leukoencephalopathy (PML) and its associated immune reconstitution inflammatory syndrome (PML-IRIS), the therapeutic options are still under investigated. In this context, the beneficial use of maraviroc is s...

journal_title：Journal of the neurological sciences

authors： Scarpazza C,Prosperini L,Mancinelli CR,De Rossi N,Lugaresi A,Capobianco M,Moiola L,Naldi P,Imberti L,Gerevini S,Capra R

更新日期：2017-07-15 00:00:00

abstract：:Bilateral striatal necrosis (BSN) has many causes and is characterized by unique clinical and neuroradiological features. Herein, we report a clinical and genetic analysis of three BSN cases from two independent Japanese families harboring a mitochondrial DNA (mtDNA) 14459G>A mutation located in a coding region of the...

journal_title：Journal of the neurological sciences

authors： Hirayanagi K,Okamoto Y,Takai E,Ishizawa K,Makioka K,Fujita Y,Kaneko Y,Tanaka M,Takashima H,Ikeda Y

更新日期：2017-07-15 00:00:00

abstract：BACKGROUND:Although single-photon emission computerized tomography of the dopamine transporter (DAT-SPECT) is useful for diagnosing parkinsonian syndrome, its applicability toward the early phase of Parkinson's disease remains unknown. METHODS:We enrolled 32 patients showing parkinsonism with normal cardiac 123I-metai...

journal_title：Journal of the neurological sciences

authors： Niimi Y,Ito S,Murate K,Hirota S,Hikichi C,Ishikawa T,Maeda T,Nagao R,Shima S,Mizutani Y,Ueda A,Mutoh T

更新日期：2017-06-15 00:00:00

abstract：:Previously, we have shown that the N-methyl d-aspartate (NMDA)-receptor antagonist kynurenic acid (KYNA) and its analogue KYNA1 do not bind directly to mu, kappa and delta opioid receptors in vitro. On the other hand, chronic administration of KYNA and KYNA1 resulted in region (cortex vs striatum) and opioid receptor-...

journal_title：Journal of the neurological sciences

authors： Samavati R,Zádor F,Szűcs E,Tuka B,Martos D,Veres G,Gáspár R,Mándity IM,Fülöp F,Vécsei L,Benyhe S,Borsodi A

更新日期：2017-05-15 00:00:00

abstract：:Alzheimer's disease (AD) is a complex disorder and the most common form of neurodegenerative dementia. Several genetic, environmental, and physiological factors, including inflammations and metabolic influences, are involved in the progression of AD. Inflammations are composed of complicated networks of many chemokine...

journal_title：Journal of the neurological sciences

authors： Bagyinszky E,Giau VV,Shim K,Suk K,An SSA,Kim S

更新日期：2017-05-15 00:00:00

abstract：:The current definition of paroxysmal atrial fibrillation (PAF) requires an arbitrary cut-off of >30s, but in clinical practice cryptogenic stroke (CS) patients with PAF duration of ≤30s are not usually excluded from anticoagulation therapy. We sought to evaluate the clinical relevance of short-duration (≤30s) PAF in C...

journal_title：Journal of the neurological sciences

authors： Liantinioti C,Tympas K,Katsanos AH,Parissis J,Chondrogianni M,Zompola C,Papadimitropoulos G,Ioakeimidis M,Triantafyllou S,Roussopoulou A,Voumvourakis K,Lekakis J,Filippatos G,Stefanis L,Tsivgoulis G

更新日期：2017-05-15 00:00:00

abstract：INTRODUCTION:The relationship between on-treatment platelet reactivity and cerebral micro-embolic signals (MES) is unknown, and has not been previously simultaneously assessed in asymptomatic and symptomatic carotid stenosis patients. METHODS:Consecutive eligible patients with ≥50% asymptomatic or recently symptomatic...

journal_title：Journal of the neurological sciences

authors： Kinsella JA,Oliver Tobin W,Tierney S,Feeley TM,Egan B,Coughlan T,Ronan Collins D,O'Neill D,Harbison JA,Doherty CP,Madhavan P,Moore DJ,O'Neill SM,Colgan MP,Saqqur M,Murphy RP,Moran N,Hamilton G,McCabe DJH

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Current American Stroke Association guidelines recommend initiating intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) within 60min of patient arrival, given the benefits of IVT for AIS are time dependent. This study aimed to identify the delaying factors in door-to-needle time (DTN) in the emerg...

journal_title：Journal of the neurological sciences

authors： Mowla A,Doyle J,Lail NS,Rajabzadeh-Oghaz H,Deline C,Shirani P,Ching M,Crumlish A,Steck DA,Janicke D,Levy EI,Sawyer RN

更新日期：2017-05-15 00:00:00

abstract：:Mitochondrial dysfunction aggravates ischemic neuronal injury through activation of various pathophysiological and molecular mechanisms. Ischemic neuronal injury is particularly intensified during reperfusion due to impairment of mitochondrial function. Mitochondrial mutilation instigates alterations in calcium homeos...

journal_title：Journal of the neurological sciences

authors： Bakthavachalam P,Shanmugam PST

更新日期：2017-04-15 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) and allergies are both considered to be related to imbalanced Th1 and Th2 immune responses. Previous studies evaluating the relationship between MS and allergies provide conflicting results. OBJECTIVE:To assess allergies and asthma as risk factors for MS and as predictors of MS relap...

journal_title：Journal of the neurological sciences

authors： Bourne T,Waltz M,Casper TC,Kavak K,Aaen G,Belman A,Benson L,Candee M,Chitnis T,Graves J,Greenberg B,Gorman M,Harris Y,Krupp L,Lotze T,Mar S,Ness J,Olsen C,Roalstad S,Rodriguez M,Rose J,Rubin J,Schreiner T,Ti

更新日期：2017-04-15 00:00:00

abstract：BACKGROUND:VTI1A and ETFA were identified recently as susceptibility genes for non-glioblastoma (GBM) of glioma risk in European populations, but the genetic etiology and pathogenesis of glioma have not been fully elucidated. Here, we aimed to investigate whether common genetic variants in VTI1A and ETFA predispose Han...

journal_title：Journal of the neurological sciences

authors： Wang N,Deng Z,Wang M,Li R,Xu G,Bao G

更新日期：2017-04-15 00:00:00

abstract：:Several single gene disorders can potentially be overlooked in the differential diagnostic evaluation of patients with multiple sclerosis (MS). Pelizaeus-Merzbacher disease and spastic paraplegia type 2 are allelic X-linked disorders associated with defective myelination of the central nervous system and mutations in ...

journal_title：Journal of the neurological sciences

authors： Rubegni A,Battisti C,Tessa A,Cerase A,Doccini S,Malandrini A,Santorelli FM,Federico A

更新日期：2017-04-15 00:00:00

abstract：:Low 25-hydroxy vitamin D (25-[OH]-D) serum concentrations have been associated with higher disease activity in multiple sclerosis (MS) patients. In a large cross-sectional study we assessed the vitamin D status in MS patients in relation to seasonality and relapse rate. 415 MS-patients (355 relapsing-remitting MS and ...

journal_title：Journal of the neurological sciences

authors： Hartl C,Obermeier V,Gerdes LA,Brügel M,von Kries R,Kümpfel T

更新日期：2017-04-15 00:00:00

abstract：:Friedreich Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder most commonly caused by guanine-adenine-adenine (GAA) trinucleotide repeat expansions in both alleles of the FXN gene. Although progressive ataxia remains the hallmark clinical feature, patients with FRDA are at high risk of developing cardi...

journal_title：Journal of the neurological sciences

authors： McCormick A,Shinnick J,Schadt K,Rodriguez R,Addonizio L,Hirano M,Perlman S,Lin KY,Lynch DR

更新日期：2017-04-15 00:00:00

abstract：:Abnormal behavior in Parkinson's disease (PD) stems from a complex orchestration of impaired neural networks that result from PD-related neurodegeneration across multiple levels. Typically, cellular and tissue abnormalities generate neurochemical changes and disrupt specific regions of the brain, in turn creating impa...

journal_title：Journal of the neurological sciences

authors： Ehgoetz Martens KA,Lewis SJ

更新日期：2017-03-15 00:00:00

abstract：:Affective disorders and personality changes have long been considered pre-motor aspects of Parkinson's disease (PD). Many authors have used the term "premorbid personality" to define distinctive features of PD patients' personality characterized by reduced exploration of new environmental stimuli or potential reward s...

journal_title：Journal of the neurological sciences

authors： Santangelo G,Piscopo F,Barone P,Vitale C

更新日期：2017-03-15 00:00:00

abstract：:Hallucinations and psychosis can be a part of Parkinson's disease and are considered to be a nonmotor symptom or a neuropsychiatric complication of the disease. Hallucinations of different modalities and delusions can occur beyond the common visual hallucinations. The various types of hallucinations and psychotic symp...

journal_title：Journal of the neurological sciences

authors： Frei K,Truong DD

更新日期：2017-03-15 00:00:00

abstract：:Gulf War veterans meeting criteria for Haley Syndrome 2 of Gulf War illness endorse a particular constellation of symptoms that include difficulty with processing information, word-finding, and confusion. To explore the neural basis of their word-finding difficulty, we assessed event-related potentials (ERPs) associat...

journal_title：Journal of the neurological sciences

authors： Tillman GD,Calley CS,Buhl VI,Chiang HS,Haley RW,Hart J Jr,Kraut MA

更新日期：2017-02-15 00:00:00

abstract：OBJECTIVES:Tumor necrosis factor-alpha inhibitors (TNFα-I) are biological agents used in the treatment of rheumatologic disorders. TNFα-I have been associated with demyelinating disorders mimicking multiple sclerosis. The goal of this report is to illustrate cases of myelopathy which developed during the use of TNFα-I....

journal_title：Journal of the neurological sciences

authors： Barreras P,Mealy MA,Pardo CA

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND AND OBJECTIVE:To study what comorbid conditions were present at baseline and 3years later in a cohort of Spanish Parkinson's disease (PD) patients, to compare comorbidity with both Alzheimer's disease (AD) and control groups and to analyze the role of comorbidity as predictor of mortality. METHODS:One hundr...

journal_title：Journal of the neurological sciences

authors： Santos García D,Suárez Castro E,Expósito I,de Deus T,Tuñas C,Aneiros A,López Fernández M,Núñez Arias D,Bermúdez Torres M

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE) is a monogenetic disease with progressive calcification of arteries and potential risk of stroke. To gain insights in the cerebral involvement in PXE, we evaluated prevalence and determinants of cerebral disease in our PXE cohort and performed a systematic review of literature....

journal_title：Journal of the neurological sciences

authors： Kauw F,Kranenburg G,Kappelle LJ,Hendrikse J,Koek HL,Visseren FLJ,Mali WPT,de Jong PA,Spiering W

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Longitudinally extensive transverse myelitis (LETM) is a frequent manifestation of neuromyelitis optica spectrum disorder (NMOSD). However, it can also occur in other immune-mediated diseases of the central nervous system (CNS). Positive aquoporin-4 antibodies (AQP4-ab) predict higher relapse rate after LETM...

journal_title：Journal of the neurological sciences

authors： Carnero Contentti E,Hryb JP,Morales S,Gomez A,Chiganer E,Di Pace JL,Lessa C,Perassolo M

更新日期：2017-02-15 00:00:00

abstract：:Anhedonia is one of the non-motor symptoms observed in the Parkinson's disease (PD). However, there is no clear relationship between anhedonia and its correlation with other symptoms of PD. The aim of this study is to evaluate the characteristics of anhedonia and its correlation with clinical aspects of PD in a relati...

journal_title：Journal of the neurological sciences

authors： Nagayama H,Maeda T,Uchiyama T,Hashimoto M,Nomoto N,Kano O,Takahashi T,Terashi H,Hamada S,Hasegawa T,Hatano T,Takahashi T,Baba Y,Sengoku R,Watanabe H,Inoue M,Kadowaki T,Kaneko S,Shimura H,Kubo SI,Young Japanese Exp

更新日期：2017-01-15 00:00:00

abstract：PURPOSE:To prospectively evaluate the usage of intra-voxel incoherent motion (IVIM) magnetic resonance imaging (MRI) parameters in grading and differentiating histological subtypes of meningiomas and in comparing their ability with the traditional diffusion-weighted imaging (DWI) parameter (apparent diffusion coefficie...

journal_title：Journal of the neurological sciences

authors： Yiping L,Kawai S,Jianbo W,Li L,Daoying G,Bo Y

更新日期：2017-01-15 00:00:00

abstract：:Gait impairment is one of the most frequent and life-altering consequences of Multiple sclerosis (MS), frequently associated with lower limb spasticity. Focal muscle vibration (fMV) is a technique that applies a vibratory stimulus to a specific muscle or its tendon, reducing spasticity. The aim of our study is to eval...

journal_title：Journal of the neurological sciences

authors： Camerota F,Celletti C,Di Sipio E,De Fino C,Simbolotti C,Germanotta M,Mirabella M,Padua L,Nociti V

更新日期：2017-01-15 00:00:00

abstract：OBJECTIVE:To investigate the cortical metabolic alterations that precedes longitudinal cognitive decline in Parkinson's disease (PD). METHODS:We analyzed the data of 46 PD patients who did not have dementia at baseline and completed 3-year follow-up. Based on the results of general cognitive, memory and visuospatial t...

journal_title：Journal of the neurological sciences

authors： Baba T,Hosokai Y,Nishio Y,Kikuchi A,Hirayama K,Suzuki K,Hasegawa T,Aoki M,Takeda A,Mori E

更新日期：2017-01-15 00:00:00

abstract：BACKGROUND:Transverse myelitis is the common presentation in demyelinating conditions. OBJECTIVE:To determine the characteristics of spinal lesions among each type of demyelinating diseases. METHODS:Medical records and spinal imaging of patients who were [1] older than 18years, [2] had at least one attack of TM, [3] ...

journal_title：Journal of the neurological sciences

authors： Dumrikarnlert C,Siritho S,Chulapimphan P,Ngamsombat C,Satukijchai C,Prayoonwiwat N

更新日期：2017-01-15 00:00:00

abstract：:The cerebrospinal fluid tap test (CSFTT) is widely used to diagnose idiopathic normal pressure hydrocephalus (iNPH) and predict the therapeutic effectiveness of shunting. However, the ability to walk cannot be quantified for patients who are unable to walk. Therefore, we examined whether the iNPH diagnostic aid is pos...

journal_title：Journal of the neurological sciences

authors： Matsuoka T,Iida JI,Kawahara M,Uchiyama Y

更新日期：2016-12-15 00:00:00

abstract：OBJECTIVE:HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) can progress slowly or rapidly even though a set of symptoms such as spastic paraparesis with pathological reflexes and sweating loss of the lower extremities are commonly observed in patients. Although most of the patients are thought to be ...

journal_title：Journal of the neurological sciences

authors： Matsuura E,Nozuma S,Tashiro Y,Kubota R,Izumo S,Takashima H

更新日期：2016-12-15 00:00:00